50/50

Joseph Gordon-Levitt

Adam Lerner

Seth Rogen

Kyle Hirons

Anna Kendrick

Katherine McKay

Bryce Dallas Howard

Rachael

Anjelica Huston

Diane Lerner

Serge Houde

Richard Lerner

Philip Baker Hall

Alan

Matt Frewer

Mitch

Andrew Airlie

Dr. Ross

Peter Kelamis

Phil

Jessica Parker Kennedy

Jackie

Sugar Lyn Beard

Susan

Donna Yamamoto

Dr. Walderson

Yee Jee Tso

Dr. Lee

Sarah Smyth

Jenny

Daniel Bacon

Dr. Phillips

P. Lynn Johnson

Bernie

Laura Bertram

Claire

Matty Finochio

Ted

Marie Avgeropoulos

Allison

Luisa d'Oliveira

Agabelle Loogenburgen

Veena Sood

Nurse Stewart

Andrea Brooks

Attractive Woman #2

Beatrice King

Pretty Girl

Chilton Crane

Mother on the Bus

Lauren Miller Rogen

Bodie

Jason Vaisvila

Cute Guy with Dreads

Brent Sheppard

Minister

Stephanie Belding

Friendly Nurse

Ryan W. Smith

Joe

William 'Big Sleeps' Stewart

George

Amitai Marmorstein

Young Person on the Bus

Will Reiser

Greg

Christopher De-Schuster

Art Gallery Patron

Adrian Glynn McMorran

Bartender

Karen van Blankenstein

Nurse Scott

Richard C. Burton

Thom the Patient

Susan De West

Bar Girl

Neil Corbett

Hospital Tech

Stephen Colbert

Self (archive footage) (uncredited)

D. C. Douglas

Live Volcano Reporter (voice) (uncredited)

Cameron K. Smith

Chemo Patient (uncredited)

Tom MacNeill

Office Staff (uncredited)