FOX 25th Anniversary Special

Ryan Seacrest

Self - Host

Christina Applegate

Self

Katey Sagal

Self

Ed O'Neill

Self

David Faustino

Self

Seth MacFarlane

Self

Evan Marriott

Self

David Duchovny

Self

Gillian Anderson

Self

Chris Carter

Self

Calista Flockhart

Self

Kelsey Grammer

Self

Katy Perry

Self

Shannen Doherty

Self

Gabrielle Carteris

Self

Jason Priestley

Self

Ian Ziering

Self

Terry Bradshaw

Self

Joe Buck

Self

Hugh Laurie

Self

Kiefer Sutherland

Self

Carrie Underwood

Self

Ashton Kutcher

Self

Mila Kunis

Self

Laura Prepon

Self

Wilmer Valderrama

Self

Keenen Ivory Wayans

Self

Marlon Wayans

Self

Tommy Davidson

Self

Shawn Wayans

Self

Dan Castellaneta

Homer Simpson (voice) (uncredited)

Nancy Cartwright

Bart Simpson (voice) (uncredited)

Julie Kavner

Marge Simpson (voice) (uncredited)

Yeardley Smith

Lisa Simpson (voice) (uncredited)

Zooey Deschanel

Self (voice) (uncredited)

Hank Azaria

Moe Szyslak (voice) (uncredited)

Mike Henry

Cleveland Brown (voice) (uncredited)

Dan Mintz

Tina Belcher (voice) (uncredited)

Eugene Mirman

Gene Belcher (voice) (uncredited)

John Roberts

Linda Belcher (voice) (uncredited)

H. Jon Benjamin

Bob Belcher (voice) (uncredited)

Kristen Schaal

Louise Belcher (voice) (uncredited)

Jim Carrey

Self (archive footage) (uncredited)

Jennifer Lopez

Self (archive footage) (uncredited)