Slither

Nathan Fillion

Bill Pardy

Michael Rooker

Grant Grant

Elizabeth Banks

Starla Grant

Gregg Henry

Jack MacReady

Tania Saulnier

Kylie Strutemyer

Don Thompson

Wally

Brenda James

Brenda Gutierrez

Jennifer Copping

Margaret

Jenna Fischer

Shelby

Haig Sutherland

Trevor

William MacDonald

Mr. Strutemyer

Iris Quinn

Mrs. Strutemyer

Matreya Fedor

Emily Strutemyer

Amber Lee Bartlett

Jenna Strutemyer

Xantha Radley

Uptight Mom

Dustin Milligan

Drawing Boy

Lloyd Kaufman

Sad Drunk

Zak Ludwig

Gina Kid

Tom Heaton

Tourneur

Mary Black

Woman in Basement

Ben Cotton

Charlie

Lorena Gale

Janene

Dee Jay Jackson

Dwight

Nicholas Podbrey

Diseased Grant part 1

Malcolm Scott

Dude Joining Grant

Darren Shahlavi

Brenda's Husband

Kathryn Kirkpatrick

Karaoke Woman

Corb Lund

Lead Singer

Michael Cromien

Fitzgibbon

Robert Musnicki

Diseased Leader

Stephen Park

Gleeked on Guy

Nicholas Podbrey

Diseased Grant #1

Jeny Cassady

Diseased Grant #2

Alette Falle

Diseased Grant #3

Matt McInnis

Head-Shot Norman

James Gunn

Hank (uncredited)

Magda Apanowicz

Friend (uncredited)

Rick Morwick

Truck Driver (uncredited)

Rob Zombie

Dr. Karl (voice)

Mark Torgl

Melvin Junko (Archive footage)